After I set GOTMLS to block XML-RPC, Jetpack lost connection between my site and WordPress. I found the answer on somebody’s blog (I wish I could remember whose!)
You need to put this in your .htaccess
file:
<Files xmlrpc.php>
Order Deny,Allow
Deny from all
Allow from wordpress.com
Allow from 192.0.64.0/18
Satisfy All
</Files>
After this, you can let the plugin block XML-RPC requests, WordPress will still be able to do its thing.
Check your Jetpack connection here: https://jetpack.com/support/debug/